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Article

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond

26 Sept 2016

Abstract excerpt

The main proteinaceous component of the keratohyalin granules within the granular layer keratinocytes of the epidermis is the giant, repetitive polyprotein profilaggrin. When granular layer cells commit to terminal differentiation to form the flattened squames of the stratum corneum, profilaggrin is rapidly cleaved into multiple copies of the 37 kDa filaggrin monomer, which binds to and condenses the keratin...

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PMID: 27667308
DOI: 10.1111/bjd.14997

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