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Article

U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas.

Clinical and experimental pharmacology & physiology - 1 Jul 2022

Chen Chuanhui, Zhou Pinglang, Zhang Zhizhe, Liu Yu

Abstract excerpt

The recurrent mutation (S34F) in splicing factor U2AF1 is frequently observed in lung adenocarcinoma, but its function remains largely unknown. To determine the mechanistic basis and consequences of U2AF1 mutations, we established non-small cell lung carcinoma A549 cell lines with exogenous expression of wildtype (U2AF1-WT) or mutant (U2AF1-S34F). Splicing analysis revealed that U2AF1-S34F mainly caused aberrant...

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Identifiers

PMID: 35434831
DOI: 10.1111/1440-1681.13646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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