Article

Nanopore sequencing reveals <i>U2AF1 S34F</i> -associated full-length isoforms

2019-12-10

Abstract excerpt

U2AF1 S34F is one of the most recurrent splicing factor mutations in lung adenocarcinoma (ADC) and has been shown to cause transcriptome-wide pre-mRNA splicing alterations. While U2AF1 S34F -associated splicing alterations have been described, the function of altered mRNA isoform changes remains largely unexplored. To better understand the impact U2AF1 S34F has on isoform fate and function, we conducted high-thr...

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Literature Corpus work: e77b9562-8e90-5c8f-934d-159568a76477
DOI: 10.1101/871863

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