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Article

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

PLoS genetics - 1 Oct 2016

Fei Dennis Liang, Motowski Hayley, Chatrikhi Rakesh, Prasad Sameer, Yu Jovian, Gao Shaojian, Kielkopf Clara L, Bradley Robert K, Varmus Harold

Abstract excerpt

We have asked how the common S34F mutation in the splicing factor U2AF1 regulates alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this mutation. A human lung epithelial cell line was genetically modified so that U2AF1S34F is expressed from one of the two endogenous U2AF1 loci. By altering levels of mutant or wild-type U2AF1 in this cell line and by analyzing published data...

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Identifiers

PMID: 27776121
DOI: 10.1371/journal.pgen.1006384
PMCID: PMC5077151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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