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Article

Unravelling the role of NFE2L1 in stress responses and related diseases

14 Jul 2023

Abstract excerpt

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance lies in its control over redox balance, proteasome activity, and organ integrity. Stress responses encompass a series of compensatory adaptations utilized by cells and organisms to cope with extracellular or intracellular stress...

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PMID: 37473701
DOI: 10.1016/j.redox.2023.102819

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