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Article

Ferroptosis Regulation by the NGLY1/NFE2L1 Pathway

2021-10-12

Abstract excerpt

Ferroptosis is an oxidative form of non-apoptotic cell death whose transcriptional regulation is poorly understood. Cap’n’collar (CNC) transcription factors including Nuclear Factor Erythroid-2 Related Factor 1 (NFE2L1/NRF1) and NFE2L2 (NRF2) are important regulators of oxidative stress responses. Here, we report that NFE2L1 expression inhibits ferroptosis, independent of NFE2L2. NFE2L1 inhibits ferroptosis by pro...

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Identifiers and source

Literature Corpus work
365b4d82-c60a-51ae-b776-df3689565c9e
DOI
10.1101/2021.10.12.463965
Open publication

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Ferroptosis Regulation by the NGLY1/NFE2L1 PathwayDOI 10.1101/2021.10.12.463965
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