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NFE2L1-mediated proteasome function protects from ferroptosis

6 Jan 2022

Abstract excerpt

OBJECTIVE: Ferroptosis continues to emerge as a novel modality of cell death with important therapeutic implications for a variety of diseases, most notably cancer and degenerative diseases. While susceptibility, initiation, and execution of ferroptosis have been linked to reprogramming of cellular lipid metabolism, imbalances in iron-redox homeostasis, and aberrant mitochondrial respiration, the detailed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34999280
DOI: 10.1016/j.molmet.2022.101436

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