Article

NRF2, a Superstar in Ferroptosis

2023-08-23

Abstract excerpt

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor E2 related factor 2 (NFE2L2, also known as NRF2) is key for cellular antioxidant responses, which promotes downstream gene transcription by binding to their antioxidant response elements (AREs). Numerous studies suggest that NRF2 assumes an extreme...

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Literature Corpus work: 297c9e16-f20a-5deb-9304-b9c3271b393f
DOI: 10.20944/preprints202308.1554.v1

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