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Corticolimbic network perturbations in early psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography study

2025-09-12

Abstract excerpt

<h4>Background: </h4> Hippocampal hyperactivity in early psychosis may result from excitation-inhibition imbalance within corticolimbic regions. Preclinical evidence suggests that positive allosteric modulation of hippocampal inhibitory γ-aminobutyric acid receptors (α5-GABAAR) attenuates hippocampal hyperactivity, striatal hyperdopaminergia, and psychosis-relevant behaviours. Here, we investigated whether hippoca...

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Literature Corpus work
17808d67-cf98-5b2a-a54f-a69b17462192
DOI
10.1101/2025.09.11.25335038
Open publication

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Corticolimbic network perturbations in early psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography studyDOI 10.1101/2025.09.11.25335038
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