Article

Effects of Diazepam on Hippocampal Blood Flow in People at Clinical High Risk for Psychosis

2024-01-04

Abstract excerpt

<h4>Background</h4> Elevated hippocampal perfusion has been observed in people at clinical high-risk for psychosis (CHR-P). Preclinical evidence suggests that hippocampal hyperactivity is central to the pathophysiology of psychosis, and that prophylactic treatment with diazepam during adolescence can prevent the development of psychosis-relevant phenotypes. Here we examined whether diazepam normalises hippocampal...

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Literature Corpus work: f8943fd2-c068-5306-a8ad-a51756bbeddb
DOI: 10.1101/2024.01.03.23299658

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