Article

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis

2026-06-04

Abstract excerpt

Extended duration of under-treated psychosis (DUP) is among the strongest predictors of poor outcome, yet diagnostic heterogeneity impedes treatment matching, with approximately 50% of patients failing to respond to first-line antipsychotics. Negative symptoms and cognitive impairment are particularly refractory, lacking effective pharmacological treatments. Identifying neurotransmitter systems associated with spe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 216b2295-3c6e-5695-aa44-17a2b7873148
DOI: 10.64898/2026.06.03.729892

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early PsychosisDOI 10.64898/2026.06.03.729892Read

Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early PsychosisSemantic proximity Read

Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric PatientsSemantic proximity Read

Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent CohortsSemantic proximity Read

Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosisSemantic proximity Read

Mapping brain-behavior space relationships along the psychosis spectrumSemantic proximity Read

Mapping Brain-Behavior Space Relationships Along the Psychosis SpectrumSemantic proximity Read

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosisSemantic proximity Read

Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis.Semantic proximity Read

Connectivity patterns of task-specific brain networks allow individual prediction of cognitive symptom dimension of schizophrenia and link to molecular architectureSemantic proximity Read

Common Substrates of Early Illness Severity: Clinical, Genetic, and Brain EvidenceSemantic proximity Read

Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.Semantic proximity Read

Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivitySemantic proximity Read