Article

Increased rostral medial frontal GABA+ in early psychosis is obscured by levels of negative affect

2022-09-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Evidence suggests dysfunction of GABAergic interneurons in psychosis, and prior research has linked GABAergic function with a tendency toward negative affective states. Magnetic resonance spectroscopy (MRS) studies measuring GABA have yielded inconsistent findings. We investigate GABA concentrations in young adults with attenuated psychosis syndrome (APS) and first episode psy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f63b583c-17f1-5b60-bbfe-35de2c1c669a
DOI: 10.1101/2022.08.30.22279365

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased rostral medial frontal GABA+ in early psychosis is obscured by levels of negative affectDOI 10.1101/2022.08.30.22279365Read

Glutamate/GABA+ ratio is associated with the psychosocial domain of autistic and schizotypal traits.Semantic proximity Read

Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy.Semantic proximity Read

Excitatory inhibitory imbalance underlies hippocampal atrophy in individuals with 22q11.2 Deletion Syndrome with psychotic symptomsSemantic proximity Read

Corticolimbic network perturbations in early psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography studySemantic proximity Read

Association between increased anterior cingulate glutamate and psychotic-like symptoms, but not autistic traitsSemantic proximity Read

A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganizationSemantic proximity Read

Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders.Semantic proximity Read

GABA<sub>A</sub>receptor availability in clinical high-risk and first-episode psychosis: a [<sup>11</sup>C]Ro15-4513 positron emission tomography studySemantic proximity Read

Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy studySemantic proximity Read

Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopySemantic proximity Read

Convergent Multimodal Evidence of Cortical Excitation-Inhibition Imbalance in PsychosisSemantic proximity Read

Glutamate, NAA and Energy Metabolism in Clinical High Risk and First Episode PsychosisSemantic proximity Read