Article

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

2021-04-09

Abstract excerpt

Current chemotherapy against Mycobacterium tuberculosis ( Mtb ), an important human pathogen, requires a multidrug regimen lasting several months. While efforts have been made to optimize therapy by exploiting drug-drug synergies, testing new drug combinations in relevant host environments remains arduous. In particular, host environments profoundly affect the bacterial metabolic state and drug efficacy, limitin...

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Literature Corpus work: 285406ef-9a8e-5b36-aeec-4ee1a5008691
DOI: 10.1101/2021.04.08.439092

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