Article
Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.
Nature genetics - 1 May 2016
Desjardins Christopher A, Cohen Keira A, Munsamy Vanisha, Abeel Thomas, Maharaj Kashmeel, Walker Bruce J, Shea Terrance P, Almeida Deepak V, Manson Abigail L, Salazar Alex, Padayatchi Nesri, O'Donnell Max R, Mlisana Koleka P, Wortman Jennifer, Birren Bruce W, Grosset Jacques, Earl Ashlee M, Pym Alexander S
Abstract excerpt
A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs such as D-cycloserine. Here we used the whole-genome sequences from 498 strains of M. tuberculosis to identify new resistance-conferring genotypes. By combining association and correlated evolution tests with strategies...
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