Article
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.
Nature genetics - 1 Oct 2013
Safi Hassan, Lingaraju Subramanya, Amin Anita, Kim Soyeon, Jones Marcus, Holmes Michael, McNeil Michael, Peterson Scott N, Chatterjee Delphi, Fleischmann Robert, Alland David
Abstract excerpt
To study the evolution of drug resistance, we genetically and biochemically characterized Mycobacterium tuberculosis strains selected in vitro for ethambutol resistance. Mutations in decaprenylphosphoryl-β-D-arabinose (DPA) biosynthetic and utilization pathway genes Rv3806c, Rv3792, embB and embC...
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