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Article

Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis.

PLoS pathogens - 1 Aug 2026

Frey Abigail M, Babunovic Gregory H, Culviner Peter H, Wang Xin, Meirav Ella, Gan Mingyu, Zhu Junhao, Moody D Branch, Liu Qingyun, Fortune Sarah M

Abstract excerpt

Antibiotic pressure causes pathogens to evolve many forms of altered drug susceptibility. In addition to target or activator mutations conferring canonical drug resistance, mutations can serve as steppingstones to or enhancers of resistance. In clinical strains of Mycobacterium tuberculosis (Mtb), we find that idsA2, which encodes an isoprenyl pyrophosphate synthase involved in the synthesis of precursors for...

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Identifiers

PMID: 42599987
DOI: 10.1371/journal.ppat.1014237
PMCID: PMC13497261

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