Article
Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2).
The Journal of biological chemistry - 13 Aug 2010
Boyd Mette, Hansen Morten, Jensen Tine G K, Perearnau Anna, Olsen Anders K, Bram Lotte L, Bak Mads, Tommerup Niels, Olsen Jørgen, Troelsen Jesper T
Abstract excerpt
The CDX2 transcription factor is known to play a crucial role in inhibiting proliferation, promoting differentiation and the expression of intestinal specific genes in intestinal cells. The overall effect of CDX2 in intestinal cells has previously been investigated in conditional knock-out mice, revealing a critical role of CDX2 in the formation of the normal intestinal identity. The identification of direct...
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