Back to search

Article

A Haptoglobin (HP) Structural Variant Alters the Effect of <i>APOE</i> Alleles on Alzheimer’s Disease

2022-09-23

Abstract excerpt

<h4>Background</h4> Haptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid-β (Aβ) to aid its clearance. A common structural variant of the HP gene distinguishes it into two alleles: HP1 and HP2 . <h4>Methods</h4> HP genotypes were imputed in 29 cohorts from the Alzheimer’s Disease (AD) Genetics Consortium (N=22,651). Associations between...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
17362f16-4f18-52d1-bdd0-03b1b3094d0c
DOI
10.1101/2022.09.22.508749
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Haptoglobin (HP) Structural Variant Alters the Effect of <i>APOE</i> Alleles on Alzheimer’s DiseaseDOI 10.1101/2022.09.22.508749
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease.Semantic proximity
Inter- and intra-chromosomal modulators of the <i>APOE</i> ε2 and ε4 effects on the Alzheimer’s disease riskSemantic proximity
Ancestry-specific effects of <i>APOE</i> on Alzheimer Disease EndophenotypesSemantic proximity
Causal Effects of Plasma Haptoglobin Levels on Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.Semantic proximity
The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.Semantic proximity
<i>APOE</i>missense variant R145C is associated with increased Alzheimer’s disease risk in African ancestry individuals with the<i>APOE ε3/ε4</i>genotypeSemantic proximity
APOE Haplotype Phasing Using ONT Long-Read Sequencing Reveals Two Common ε3 and ε4 intragenic haplotypes in the Spanish PopulationSemantic proximity
Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans.Semantic proximity
Protein phosphatase 2A, complement component 4, and <i>APOE</i> genotype linked to Alzheimer’s disease using a systems biology approachSemantic proximity
Is <i>APOE ε2</i> always a protective allele? Deviations in Hardy-Weinberg equilibrium in admixed Brazilian elderly individualsSemantic proximity
Challenges at the <i>APOE</i> locus: A robust quality control approach for accurate <i>APOE</i> genotypingSemantic proximity
How does Apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative modelSemantic proximity
Select a neighboring publication to make it the new centre.