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Article

A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2023

Bai Haimeng, Naj Adam C, Benchek Penelope, Dumitrescu Logan, Hohman Timothy, Hamilton-Nelson Kara, Kallianpur Asha R, Griswold Anthony J, Vardarajan Badri, Martin Eden R, Beecham Gary W, Below Jennifer E, Schellenberg Gerard, Mayeux Richard, Farrer Lindsay, Pericak-Vance Margaret A, Haines Jonathan L, Bush William S

Abstract excerpt

BACKGROUND: Haptoglobin (HP) is an antioxidant of apolipoprotein E (APOE), and previous reports have shown HP binds with APOE and amyloid beta (Aβ) to aid its clearance. A common structural variant of the HP gene distinguishes it into two alleles: HP1 and HP2. METHODS: HP genotypes were imputed in 29 cohorts from the Alzheimer's Disease Genetics Consortium (N = 20,512). Associations between the HP polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37051669
DOI: 10.1002/alz.13050
PMCID: PMC13047925

Genes

APOE
HP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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