Article

Single-cell transcriptomics identifies different immune signatures between macrophage activation-like syndrome and immune paralysis in sepsis

2023-03-20

Abstract excerpt

Different immune phenotypes characterize sepsis patients, including hyperinflammation and/or immunosuppression, but the biological mechanisms driving this heterogeneity remain largely unknown. We used single-cell RNA sequencing to profile circulating leukocytes of healthy controls and sepsis patients classified as either hyperinflammatory (macrophage activation-like syndrome [MALS]), immune paralysis , or unclassi...

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Literature Corpus work: 1715f478-e182-5b0a-b269-935ed37795b9
DOI: 10.1101/2023.03.17.23287390

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