Sepsis endotypes identified by host gene expression across global cohorts

Abstract excerpt

BACKGROUND: Sepsis from infection is a global health priority and clinical trials have failed to deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis pathobiology, and improve outcomes, promising precision medicine approaches are helping identify disease endotypes, however, they require a more complete definition of sepsis subgroups. METHODS: Here, we use RNA sequencing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Response and Inflammation
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Sepsis Diagnosis and Treatment