Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomic Profiling Reveals Distinct Immune Dysregulation in Early-Stage Sepsis Patients

11 Jul 2025

Abstract excerpt

Sepsis is a life-threatening condition characterized by dysregulated immune responses to infection. To elucidate early transcriptional changes in sepsis, we conducted a case–control study profiling gene expression in whole blood from 20 early-stage sepsis patients and 9 healthy controls. Using Affymetrix Clariom D Human Arrays and robust preprocessing, we identified differentially expressed genes (DEGs) using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune cells in cancer
Share to Immune Response and Inflammation
Share to Sepsis Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40724897
DOI: 10.3390/ijms26146647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Profiling Reveals Distinct Immune Dysregulation in Early-Stage Sepsis PatientsPMID 40724897Read ↗

Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics AnalysisSemantic proximity Read ↗

Classification of subtypes and identification of dysregulated genes in sepsisSemantic proximity Read ↗

Identifying Key Regulatory Genes in the Whole Blood of Septic Patients to Monitor Underlying Immune DysfunctionsSemantic proximity Read ↗

A Meta-Analysis of Whole Blood Transcriptome Reveals Association of Increased Neutrophil Activity and T cell Suppression in SepsisSemantic proximity Read ↗

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.Semantic proximity Read ↗

Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illnessSemantic proximity Read ↗

Gene Expression Profiles Differentiate Between Sterile SIRS and Early SepsisSemantic proximity Read ↗

Identification of Potential Early Diagnostic Biomarkers of SepsisSemantic proximity Read ↗

Identification of deleterious neutrophil states and altered granulopoiesis in sepsisSemantic proximity Read ↗

Predicting severity in COVID-19 disease using sepsis blood gene expression signaturesSemantic proximity Read ↗

A comprehensive analysis of immune features and construction of an immune gene diagnostic model for sepsisSemantic proximity Read ↗

Identification of qualitative characteristics of immunosuppression in sepsis based on immune-related genes and immune infiltration featuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.