Article

Identification of deleterious neutrophil states and altered granulopoiesis in sepsis

2022-03-23

Abstract excerpt

Sepsis is a condition of high mortality arising from dysregulation of the host immune response. Gene expression studies have identified multiple immune endotypes but gaps remain in our understanding of the underlying biology and heterogeneity. We used single-cell multi-omics to profile 272,993 cells across 48 whole blood samples from 26 sepsis patients (9 with paired convalescent samples), 6 healthy controls and 7...

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Literature Corpus work: 4514e7fc-76b3-5479-b638-41049cca21ac
DOI: 10.1101/2022.03.22.22272723

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