Article
A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.
Frontiers in immunology - 1 Jan 2021
Darden Dijoia B, Dong Xiaoru, Brusko Maigan A, Kelly Lauren, Fenner Brittany, Rincon Jaimar C, Dirain Marvin L, Ungaro Ricardo, Nacionales Dina C, Gauthier Marie, Kladde Michael, Brusko Todd M, Bihorac Azra, Moore Frederick A, Loftus Tyler, Bacher Rhonda, Moldawer Lyle L, Mohr Alicia M, Efron Philip A
Abstract excerpt
Background: With the successful implementation of the Surviving Sepsis Campaign guidelines, post-sepsis in-hospital mortality to sepsis continues to decrease. Those who acutely survive surgical sepsis will either rapidly recover or develop a chronic critical illness (CCI). CCI is associated with adverse long-term outcomes and 1-year mortality. Although the pathobiology of CCI remains undefined, emerging evidence...
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