Article

Longitudinal Immune Profiling in Sepsis Reveals Transient Expansion of a CD14<sup>+</sup>Monocyte State and Persistent T Cell Suppression

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Sepsis is a dynamic syndrome of immune dysregulation and a leading cause of global mortality. Although immune suppression is recognized as a hallmark of sepsis, the temporal dynamics and mechanistic drivers of immune dysfunction remain incompletely understood. Here, we performed longitudinal single-cell transcriptomic and proteomic profiling of peripheral blood from 98 adults with sepsis or steri...

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Literature Corpus work: 5fe480cf-0eb0-5722-baf3-3d9fe5fe2971
DOI: 10.1101/2025.05.17.25327533

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Longitudinal Immune Profiling in Sepsis Reveals Transient Expansion of a CD14<sup>+</sup>Monocyte State and Persistent T Cell SuppressionDOI 10.1101/2025.05.17.25327533Read

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