Article

Inhibiting B-cell-mediated Immunosuppression to Enhance the Immunotherapy Efficacy in Hepatocellular Carcinoma

2025-03-07

Abstract excerpt

<h4>Background</h4> Immunotherapy is efficacious in hepatocellular carcinoma (HCC), but the benefits are limited to a minority of patients. Most HCC patients show resistance to immune checkpoint blockade (ICB). Agonists of the stimulator of interferon genes (STING), potent immune stimulators, showed limited effectiveness. Using preclinical models, we studied the mechanisms of resistance to ICB and STING agonism....

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Literature Corpus work: 491b0e96-a0b7-5fc9-9503-ec7d32959482
DOI: 10.1101/2025.03.04.641494

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