Article

Single-cell multi-omics analysis reveals heterogeneity and plasticity of neutrophil states in response to immunotherapies

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tumor-associated neutrophils (TANs) are emerging as functionally heterogeneous and plastic cells in the tumor microenvironment. In immunologically cold tumors, elevated neutrophil abundance correlates with poor prognosis and resistance to immune checkpoint inhibition (ICI). Whether distinct anti-tumoral neutrophil states can be induced by different immunotherapies and how th...

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Literature Corpus work: d2240b59-cfa9-5181-a6e8-6f0f4b8ff79b
DOI: 10.64898/2026.07.02.735691

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