Article

Selective Targeting uPAR-driven Neutrophil Extracellular Traps Functional Clusters to Attenuate Tumor Progression and Enhance the Response to Immunotherapy in Intrahepatic Cholangiocarcinoma

2026-04-09

Abstract excerpt

<title>Abstract</title> <p>Cholangiocarcinoma (CCA) is an aggressive malignancy with dismal prognosis; PD-1/PD-L1 blockade benefits few patients, as the tumor microenvironment (TME) is immunologically “cold”. A key CCA-TME feature is massive tumor-associated neutrophil (TAN) infiltration releasing neutrophil extracellular traps (NETs). Conventionally deemed pro-tumorigenic, NETs’ anti-tumor potential is overlooke...

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Literature Corpus work: aab67d5e-07a2-583d-9436-ef405ee38f25
DOI: 10.21203/rs.3.rs-9281659/v1

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