Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

doi:10.1016/s1074-7613(00)80554-3

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Article

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

Immunity - 1 Apr 1998

Cornall R J, Cyster J G, Hibbs M L, Dunn A R, Otipoby K L, Clark E A, Goodnow C C

Abstract excerpt

A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium...

Topics

Animals
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Autoantigens
Autoimmunity
B-Lymphocytes
Cell Adhesion Molecules
Female
Intracellular Signaling Peptides and Proteins
Lectins
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Knockout

Mice, Transgenic

Muramidase

Phenotype

Source

Open in PubMed

Identifiers

PMID: 9586639
DOI: 10.1016/s1074-7613(00)80554-3

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9586639-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.PMID 9586639Read ↗

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