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Article

Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.

Cell communication and signaling : CCS - 4 Sept 2018

Feng Rui, Morine Yuji, Ikemoto Tetsuya, Imura Satoru, Iwahashi Shuichi, Saito Yu, Shimada Mitsuo

Abstract excerpt

BACKGROUND: The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)-Like 2 (Nrf2) not only modulates the angiogenesis but also plays the anti-inflammatory role through inhibiting pro-inflammatory cytokines expression; however, the role of Nrf2 in the cancer cell...

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Identifiers

PMID: 30180849
DOI: 10.1186/s12964-018-0262-x
PMCID: PMC6122794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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