Article

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

2023-10-04

Abstract excerpt

<h4>ABSTRACT</h4> The Hippo pathway is among the most frequently altered key signaling pathways in cancer. TEAD1-4 are essential transcription factors and key downstream effectors in the Hippo pathway in human cells. Here, we identified RNF146 as a ubiquitin ligase (E3) of TEADs, which negatively regulates their stability in cells through proteasome-mediated degradation. We show that RNF146-mediated TEAD ubiquiti...

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Literature Corpus work: 168fb12e-03bd-5c6a-af5d-d69e18e77f60
DOI: 10.1101/2023.10.03.560675

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