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Development of a pipeline to evaluate YAP-TEAD inhibitor potential <i>-</i> direct TEAD inhibition represses cancerous growth in a <i>NF2</i> -mutant model of mesothelioma

2024-11-12

Abstract excerpt

<h4>ABSTRACT</h4> As the core, tumorigenic downstream effectors of the Hippo signalling pathway, YAP/TAZ and the TEAD family of transcription factors represent attractive targets for drug discovery efforts within cancer research. This is particularly true within the context of pleural mesothelioma, in which there are many recent preclinical developments and clinical trials evaluating the efficacy of TEAD inhibito...

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Literature Corpus work
e5ce62ea-d305-554d-911c-a71af6fc2ceb
DOI
10.1101/2024.11.12.622964
Open publication

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Development of a pipeline to evaluate YAP-TEAD inhibitor potential <i>-</i> direct TEAD inhibition represses cancerous growth in a <i>NF2</i> -mutant model of mesotheliomaDOI 10.1101/2024.11.12.622964
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