Article

An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription

2024-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Hippo signaling is one of the top pathways altered in human cancer, and intensive focus has been devoted to developing therapies targeting Hippo-dependent transcription mediated by YAP1 and TAZ interaction with TEAD proteins. However, a significant challenge in evaluating the efficacy of these approaches is the lack of models that can precisely characterize the consequences of TEAD inhibition. T...

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Literature Corpus work: b78f4adb-65b1-5b40-8735-54cd54b226d2
DOI: 10.1101/2024.10.03.615022

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