Article

The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation

2023-05-18

Abstract excerpt

<title>Abstract</title> <p>RNF214 is an understudied ubiquitin ligase without any knowledge of its biological functions or specific protein substrates. Using an APEX2-mediated proximity labeling method coupled with the mass spectrometry technique, we identified the TEAD transcription factors in the Hippo pathway as interactors of RNF214. We showed that RNF214 induces non-proteolytic ubiquitylation at a conserved...

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Literature Corpus work: 53735cf4-0539-5049-8e8a-083b39205db1
DOI: 10.21203/rs.3.rs-2832184/v1

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