Article

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> The Hippo tumour suppressor pathway controls transcription by regulating nuclear abundance of YAP and TAZ, which activate transcription with the TEAD1-TEAD4 DNA-binding proteins. Recently, several small-molecule inhibitors of YAP and TEADs have been reported, with some now entering clinical trials for different cancers. Here, we investigated the cellular response to TEAD palmitoylation inhibitor...

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Literature Corpus work: 036da155-f40b-56d2-af7a-e525a12a1cc2
DOI: 10.1101/2023.08.16.553491

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