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Article

Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies

7 Feb 2025

Abstract excerpt

Poly(ADP-ribosyl)ation (PARylation) is a dynamic protein post-translational modification (PTM) mediated by ADP-ribosyltransferases (ARTs), which regulates a plethora of essential biological processes, such as DNA repair, gene expression, and signal transduction. Among these, PAR-dependent ubiquitination (PARdU) plays a pivotal role in tagging PARylated substrates for subsequent ubiquitination and degradation...

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PMID: 40001540
DOI: 10.3390/biom15020237

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