Article

<i>De novo</i> macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

2020-12-04

Abstract excerpt

<h4>ABSTRACT</h4> The Retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signalling. Mutations in Retromer cause late-onset Parkinson’s disease, while viral and bacterial pathogens can hijack the complex during cellular infection. To modulate and probe its function we have created a novel series of macrocyclic peptides that bind Retromer with high affinity and specificity. Cr...

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Identifiers and source

Literature Corpus work: 309149ae-4e6f-56e2-933b-e509ac62a0c7
DOI: 10.1101/2020.12.03.410779

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