Article

Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm

2022-05-21

Abstract excerpt

RNA therapeutics have the potential to resolve a myriad of diseases caused by gene deficiency. Lipid nanoparticles (LNPs) are one of the most successful RNA delivery systems. However, expanding their application hinges on the discovery of next generation LNPs with high potency, cyto-specific targeting, and low side effects. Overcoming the difficulty of releasing cargo from endocytosed LNPs remains a significant hu...

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Literature Corpus work: 9c642e18-7f2b-5d09-b28d-a1ee2e09b6af
DOI: 10.1101/2022.05.20.492895

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