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Article

Plasmablast-like Phenotype Among Antigen-Experienced CXCR5-CD19low B Cells in Systemic Lupus Erythematosus.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Sept 2022

Szelinski Franziska, Stefanski Ana Luisa, Schrezenmeier Eva, Rincon-Arevalo Hector, Wiedemann Annika, Reiter Karin, Ritter Jacob, Lettau Marie, Dang Van Duc, Fuchs Sebastian, Frei Andreas P, Alexander Tobias, Lino Andreia C, Dörner Thomas

Abstract excerpt

OBJECTIVE: Altered composition of the B cell compartment in the pathogenesis of systemic lupus erythematosus (SLE) is characterized by expanded plasmablast and IgD-CD27- double-negative B cell populations. Previous studies showed that double-negative B cells represent a heterogeneous subset, and further characterization is needed. METHODS: We analyzed 2 independent cohorts of healthy donors and SLE patients,...

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Identifiers

PMID: 35507291
DOI: 10.1002/art.42157

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