Article
B cell phenotypes, signaling and their roles in secretion of antibodies in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.) - 1 Jan 2018
Tanaka Yoshiya, Kubo Satoshi, Iwata Shigeru, Yoshikawa Maiko, Nakayamada Shingo
Abstract excerpt
B cells play a pivotal role in the initiation and perpetuation of SLE. Because SLE is molecularly and clinically heterogeneous, efficacious targeted therapy to clinical remission has not yet been established in SLE. We have found i) statistical clustering between Tfh cells and class-switched memory B cells and the upregulated transition from CXCR5+ IgM memory B cells to CXCR3+ class-switched memory B cells in SLE...
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