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Article

Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.

Arthritis research & therapy - 1 Jan 2010

Rodríguez-Bayona Beatriz, Ramos-Amaya Ana, Pérez-Venegas José J, Rodríguez Carmen, Brieva José A

Abstract excerpt

INTRODUCTION: Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation. The phenotypic analysis of blood B cell subsets can be used to understand these alterations. METHODS: The combined detection of CD19, CD27 and IgD (or IgM) by flow cytometry (FC) analysis delineates five well-defined blood B cell-subsets: naive,...

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Identifiers

PMID: 20525218
DOI: 10.1186/ar3042
PMCID: PMC2911899

Genes

CXCR3
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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