Article

Unsaturated fatty acid synthesis is associated with poor prognosis and differentially regulated by <i>MYCN</i> and tumor suppressor microRNAs in neuroblastoma

2023-04-21

Abstract excerpt

<h4>ABSTRACT</h4> MYCN amplification and disruption of tumor suppressor microRNA (TSmiR) function are central drivers of poor outcomes in neuroblastoma (NB). MYC, MYCN, and TSmiRs regulate glucose metabolism; however, their role in unsaturated fatty acid synthesis (UFAS) remains poorly understood. Here we show that de novo and UFAS pathway genes FASN , ELOVL6 , SCD , FADS2 , and FADS1 are upregulated in hig...

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Literature Corpus work: 48568001-975e-54f5-82a9-3f12f6a0edbf
DOI: 10.1101/2023.04.20.537692

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