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Article

Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment.

Cell death & disease - 20 Apr 2020

Kant Shiva, Kesarwani Pravin, Prabhu Antony, Graham Stewart F, Buelow Katie L, Nakano Ichiro, Chinnaiyan Prakash

Abstract excerpt

Despite advances in molecularly characterizing glioblastoma (GBM), metabolic alterations driving its aggressive phenotype are only beginning to be recognized. Integrative cross-platform analysis coupling global metabolomic and gene expression profiling on patient-derived glioma identified fatty acid β-oxidation (FAO) as a metabolic node in GBM. We determined that the biologic consequence of enhanced FAO is...

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Identifiers

PMID: 32312953
DOI: 10.1038/s41419-020-2449-5
PMCID: PMC7170895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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