Article

Single-Cell Analysis of Meningiomas Reveals Mutation-Associated Tumor and Immune Cell Gene Expression Programs

2025-05-24

Abstract excerpt

Genomic and epigenetic profiling, particularly DNA methylation analysis, have refined the molecular classification of meningiomas and revealed marked intratumoral heterogeneity. To further characterize heterogeneity within and between patients, we analyzed meningiomas using single-cell RNA sequencing ( n =11), whole-exome sequencing ( n =9), and spatial transcriptomics ( n =3). Single-cell analysis revealed six...

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Literature Corpus work: abb03f98-18ce-5320-bd65-1f2abc16014a
DOI: 10.1101/2025.05.21.655421

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