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Article

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen <i>Citrobacter rodentium</i>

2019-03-26

Abstract excerpt

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscores IBD susceptibility, studies have yet to address how IRGM/Irgm1 regulates immunity to microbes relevant to intest...

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Literature Corpus work
5df7e93a-35a6-5946-9bfc-ecc3ccb12a07
DOI
10.1101/575415
Open publication

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