Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.

doi:10.1016/j.jare.2025.12.028

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Article

Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.

Journal of advanced research - 1 Sept 2026

Lin Jian-Da, Li Hsun, Hsu Chia-Lang, Lin Tzu-Lung, Chuang Hsiao-Li, Lin Han-I, Ho En-Peng, Chen Yi-Hsuan, Liu Chia-Wei, Chuang Ya-Ting, Lung Yun-Yi, Lien Chia-Jung, Chen Huan-Yun, Wu Wei-Kai, Wu Ming-Shiang, Lu Chia-Chen, Lai Hsin-Chih, Lin Chin-Hsien

Abstract excerpt

INTRODUCTION: Alterations in the gut microbiota accompanied by intestinal inflammation are early features of Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent a common genetic risk factor for PD and inflammatory bowel disease. Parabacteroides goldsteinii has been reported to alleviate intestinal and systemic inflammation. However, whether modulation of the gut...

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