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Article

Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease

2023-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Chronic kidney disease (CKD) accelerates the development of atherosclerosis, decreases muscle function, and increases the risk of amputation or death in patients with peripheral artery disease (PAD). However, the cellular and physiological mechanisms underlying this pathobiology are ill-defined. Recent work has indicated that tryptophan-derived uremic toxins, many of which are ligands for the ar...

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Identifiers and source

Literature Corpus work
1641165f-e4cf-5361-a387-8fc92a93db22
DOI
10.1101/2023.05.16.541060
Open publication

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Chronic activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney diseaseDOI 10.1101/2023.05.16.541060
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