Article

Uremic toxin indoxyl sulfate induces trained immunity <i>via</i> the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

2022-08-11

Abstract excerpt

Trained immunity is the long-term functional reprogramming of innate immune cells, which results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) being a potent stimulus associated with chronic kidney disease (CKD)-related inflammation, its impact on trained immunity has not been explored. Here, we demonstrate that IS induces trained immunity in monocytes via epigenetic and metaboli...

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Literature Corpus work: cee0dc62-f965-5603-86a3-72b5cb08fa38
DOI: 10.1101/2022.08.08.503143

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