The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.

doi:10.1093/ndt/gfv367

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Article

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2016

Minakuchi Hitoshi, Wakino Shu, Hosoya Kozi, Sueyasu Keiko, Hasegawa Kazuhiro, Shinozuka Keisuke, Yoshifuji Ayumi, Futatsugi Koji, Komatsu Motoaki, Kanda Takeshi, Tokuyama Hirobumi, Hayashi Koichi, Itoh Hiroshi

Abstract excerpt

BACKGROUND: The lipodystrophy-like phenotype has been suggested in early chronic kidney disease (CKD). It includes adipose tissue atrophy, systemic insulin resistance (IR), dyslipidemia and ectopic lipid accumulation. To elucidate its pathogenesis, we investigated the role of two uremic toxins that affect insulin sensitivity: an endogenous nitric oxide synthase inhibitor, and asymmetric dimethylarginine (ADMA)...

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PMID: 26516203
DOI: 10.1093/ndt/gfv367

Genes

DDAH1
DDAH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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