Article

Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery Disease

2026-01-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Peripheral artery disease (PAD) and its severe form, chronic limb-threatening ischemia (CLTI), significantly impair blood flow to the lower extremities, affecting millions of adults globally. Intramuscular adipose tissue (IMAT) and fibrosis accumulation distinguish patients with CLTI from those with mild PAD, suggesting a role in CLTI pathobiology. However, the functional co...

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Literature Corpus work: 98ee76fe-60a0-5ce0-9c73-9655a92e61aa
DOI: 10.64898/2026.01.27.701833

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